If you have a large spreadsheet to edit (ie. 10k+ columns) with your UHD display (ie. 4K or higher resolution) in Microsoft 365 Excel you may have some performance issues when scrolling.
I just found an easy hack that works for me:
- Check Disable hardware graphics acceleration in Excel under File – Options – Advanced – Display section
 - Exit Excel
 - Change your display resolution to 1920×1080
 - Change text scale to 100%
 - Open the spreadsheet you need to edit with Excel
 - Change your display resolution back to native resolution
 - Change text scale back to your original option (ie. 200%)
 - See magic happens
 
This hack works until you exit your Excel. So you have to redo step 3-8 when openning new documents.